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Article

Reduced Nitric Oxide Causes Age-Associated Impairment of Circadian Rhythmicity

25 Jan 2008

Abstract excerpt

Impairment of circadian rhythmicity in the elderly has been suggested to cause age-associated diseases such as atherosclerosis and hypertension. Endothelium-derived nitric oxide (NO) is a critical regulator of cardiovascular homeostasis, but its production declines with aging, thereby inducing vascular dysfunction. We show here that impaired circadian rhythmicity is related to a decrease of NO production with...

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Share to Circadian rhythm and melatonin
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Nitric Oxide and Endothelin Effects

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PMID: 18218984
DOI: 10.1161/circresaha.107.162230

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