“Loss of circulating glucocorticoid rhythm disrupts the circadian transcriptome and vascular reactivity in the mouse renal artery.”

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims</h4> Molecular clocks in the vasculature contribute to the normal circadian blood pressure (BP) rhythm. Glucocorticoids are known to synchronise molecular clocks within peripheral tissues. Disruption of the endogenous glucocorticoid rhythm causes “non-dipping”, a BP pattern associated with elevated cardiovascular risk. The mechanisms for this are unclear but vascular changes likely con...

Topics

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• Aldosterone
• ARNTL Transcription Factors
• Blood Vessels
• Circadian rhythm and melatonin
• CLOCK Proteins
• Cryptochromes
• Diabetes Mellitus, Experimental
• Period Circadian Proteins

Identifiers and source

Literature Corpus work

3a2a39fb-71d1-5995-978a-28dc141ada67

DOI

10.1101/2025.04.29.650449