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Article

A single amino acid mutation attenuates rundown of voltage-gated calcium channels.

FEBS letters - 16 Oct 2006

Zhen Xiao-Guang, Xie Cheng, Yamada Yoichi, Zhang Yun, Doyle Christina, Yang Jian

Abstract excerpt

The activity of voltage-gated calcium channels (VGCCs) decreases with time in whole-cell and inside-out patch-clamp recordings. In this study we found that substituting a single amino acid (I1520) at the intracellular end of IIIS6 in the alpha(1) subunit of P/Q-type Ca(2+) channels with histidine or aspartate greatly attenuated channel rundown in inside-out patch-clamp recordings. The homologous mutations also...

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Identifiers

PMID: 17010345
DOI: 10.1016/j.febslet.2006.09.027
PMCID: PMC1693970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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