Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signal processing by its coil zipper domain activates IKK gamma.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2008

Bloor Stuart, Ryzhakov Grigor, Wagner Sebastian, Butler P Jonathan G, Smith David L, Krumbach Rebekka, Dikic Ivan, Randow Felix

Abstract excerpt

NF-kappaB activation occurs upon degradation of its inhibitor I-kappaB and requires prior phosphorylation of the inhibitor by I-kappaB kinase (IKK). Activity of IKK is governed by its noncatalytic subunit IKKgamma. Signaling defects due to missense mutations in IKKgamma have been correlated to its inability to either become ubiquitylated or bind ubiquitin noncovalently. Because the relative contribution of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Jurkat Cells
Share to Leucine Zippers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adaptor Proteins, Signal Transducing

Share to Down-Regulation

Share to Enzyme Activation

Share to I-kappa B Kinase

Share to Ubiquitin

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 18216269
DOI: 10.1073/pnas.0706552105
PMCID: PMC2234129

Genes

TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal processing by its coil zipper domain activates IKK gamma.PMID 18216269Read ↗

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.Semantic proximity Read ↗

Compound heterozygous mutations in the kinase domain of IKKα lead to immunodeficiency and immune dysregulationSemantic proximity Read ↗

The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.Semantic proximity Read ↗

The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.Semantic proximity Read ↗

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.Semantic proximity Read ↗

Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.Semantic proximity Read ↗

IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.Semantic proximity Read ↗

CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules.Semantic proximity Read ↗

Phosphorylation of the CARMA1 linker controls NF-kappaB activation.Semantic proximity Read ↗

Self-association of CIITA and its transactivation potential.Semantic proximity Read ↗

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.Semantic proximity Read ↗

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.