Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs.

Nucleic acid therapeutics - 1 Jun 2014

Hu Jiaxin, Liu Jing, Yu Dongbo, Aiba Yuichiro, Lee Suheung, Pendergraff Hannah, Boubaker Jihane, Artates Jonathan W, Lagier-Tourenne Clotilde, Lima Walt F, Swayze Eric E, Prakash Thazha P, Corey David R

Abstract excerpt

Mutant huntingtin (HTT) protein is the cause of Huntington's disease (HD), an incurable neurological disorder. Almost all patients are heterozygous for mutant HTT and approaches that reduce levels of mutant HTT while leaving expression of wild-type HTT intact might be ideal options for therapeutic development. We have developed several allele-selective strategies for silencing HTT, including single-stranded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblasts
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Injections, Intraventricular

Share to Lipids

Share to RNA Interference

Share to RNA, Small Interfering

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 24694346
DOI: 10.1089/nat.2013.0476
PMCID: PMC4026301

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs.PMID 24694346Read ↗

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.Semantic proximity Read ↗

Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.Semantic proximity Read ↗

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing <i>in vivo</i> in CNSSemantic proximity Read ↗

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.Semantic proximity Read ↗

Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.Semantic proximity Read ↗

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.Semantic proximity Read ↗

An insight into allele-selective approaches to lowering mutant huntingtin protein for Huntington's disease treatment.Semantic proximity Read ↗

Personalized gene silencing therapeutics for Huntington disease.Semantic proximity Read ↗

Gene targeting techniques for Huntington's disease.Semantic proximity Read ↗

Using non-coding small RNAs to develop therapies for Huntington's disease.Semantic proximity Read ↗

Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.Semantic proximity Read ↗

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.