Article
The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression.
The Biochemical journal - 1 Jun 2008
Liu Yongqing, El-Naggar Shahenda, Clem Brian, Chesney Jason, Dean Douglas C
Abstract excerpt
Disruption of the Rb (retinoblastoma protein)/E2F cell-cycle pathway and Ras activation are two of the most frequent events in cancer, and both of these mutations place oncogenic stress on cells to increase DNA replication. In the present study, we demonstrate that these mutations have an additive effect on induction of members of the RecQ DNA helicase family. RecQ activity is important for genomic stability,...
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