Association between tryptophan hydroxylase 2, performance on a continuance performance test and response to methylphenidate in ADHD participants.

doi:10.1002/ajmg.b.30702

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Article

Association between tryptophan hydroxylase 2, performance on a continuance performance test and response to methylphenidate in ADHD participants.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2008

Manor Iris, Laiba Efrat, Eisenberg Jacques, Meidad Sheera, Lerer Elad, Israel Salomon, Gritsenko Inga, Tyano Sam, Faraone Stephen V, Ebstein Richard P

Abstract excerpt

The main objective of this study was to examine neuropsychological mechanisms mediating the association between tryptophan hydroxylase 2 (TPH2) and attention deficit hyperactivity disorder (ADHD). A continuous performance test (T.O.V.A.) was administered to 344 participants diagnosed with DSM IV ADHD who were also genotyped for eight TPH2 intronic SNPs. Association between TPH2 (single SNPs and haplotypes), ADHD,...

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Identifiers

PMID: 18213624
DOI: 10.1002/ajmg.b.30702

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TPH2

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