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Article

Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells.

Carcinogenesis - 1 Apr 2008

Chintalapudi Mastan R, Markiewicz Margaret, Kose Nurgun, Dammai Vincent, Champion Kristen J, Hoda Rana S, Trojanowska Maria, Hsu Tien

Abstract excerpt

The von Hippel-Lindau (VHL) protein serves as a negative regulator of hypoxia-inducible factor (HIF)-alpha subunits. Since HIF regulates critical angiogenic factors such as vascular endothelial growth factor (VEGF) and lesions in VHL gene are present in a majority of the highly vascularized renal cell carcinoma (RCC), it is believed that deregulation of the VHL-HIF pathway is crucial for the proangiogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18212329
DOI: 10.1093/carcin/bgn019
PMCID: PMC2288647

Genes

VHL
CCN2
CCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells.PMID 18212329Read ↗

MicroRNA profiling identifies VHL/HIF-2α dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growthSemantic proximity Read ↗

VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesisSemantic proximity Read ↗

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.Semantic proximity Read ↗

VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.Semantic proximity Read ↗

Tumor Heterogeneity in VHL Drives Metastasis in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.Semantic proximity Read ↗

VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1.Semantic proximity Read ↗

Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL-Deficient Kidney Tissue.Semantic proximity Read ↗

VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.Semantic proximity Read ↗

VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.Semantic proximity Read ↗

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.Semantic proximity Read ↗

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.Semantic proximity Read ↗

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