Article

Tumor Heterogeneity in VHL Drives Metastasis in Clear Cell Renal Cell Carcinoma

2021-09-10

Abstract excerpt

<title>Abstract</title> <p>To study the impact of intratumoral VHL heterogeneity observed in patient ccRCC primary tumors, we engineered VHL gene deletion in three RCC models, including a new primary tumor cell line derived from an aggressive metastatic ccRCC. The VHL gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and showed diminished proliferation and tumorigenicity compared to...

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Literature Corpus work: d606d0a7-76e8-560c-9067-c58b1ae7ed78
DOI: 10.21203/rs.3.rs-846239/v1

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