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Article

Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2008

Gupta Vineet, Alonso José Luis, Sugimori Takashi, Essafi Makram, Issafi Makram, Xiong Jiang-Ping, Arnaout M Amin

Abstract excerpt

Formation of the integrin alphabeta heterodimer is essential for cell surface expression and function. At the core of the alphabeta interface is a conserved Arg/Lys "finger" from the beta-subunit that inserts into a cup-like "cage" formed of two layers of aromatic residues in the alpha-subunit. We evaluated the role of this residue in heterodimer formation in an alphaA-lacking and an alphaA-containing integrin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18209068
DOI: 10.4049/jimmunol.180.3.1713
PMCID: PMC3075857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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