Article
The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding.
Biochemistry - 2 Apr 2002
Takagi Junichi, DeBottis Daniel P, Erickson Harold P, Springer Timothy A
Abstract excerpt
Integrin beta subunits contain a highly conserved I-like domain that is known to be important for ligand binding. Unlike integrin I domains, the I-like domain requires integrin alpha and beta subunit association for optimal folding. Pactolus is a novel gene product that is highly homologous to integrin beta subunits but lacks associating alpha subunits [Chen, Y., Garrison, S., Weis, J. J., and Weis, J. H. (1998)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.