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Article

p53 downregulates the Fanconi anaemia DNA repair pathway

1 Apr 2016

Abstract excerpt

Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes. Mice expressing p53(Δ31), a mutant p53 lacking the C terminus, model dyskeratosis congenita. Accordingly, the increased p53 activity in p53(Δ31/Δ31) fibroblasts correlated with a decreased expression of 4 genes implicated in...

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PMID: 27033104
DOI: 10.1038/ncomms11091

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