Article
The p53 R72P polymorphism does not influence cervical cancer development in a Portuguese population: a study in exfoliated cervical cells.
Journal of medical virology - 1 Mar 2008
Oliveira S, Sousa H, Santos A M, Pinto D, Pinto-Correia A L, Fontoura D, Moutinho J, Medeiros R
Abstract excerpt
The interaction between the E6 protein of the high-risk human papillomaviruses (HPVs) with p53 seems to be crucial in cervical carcinogenesis. The presence of Arg/Arg genotype at codon 72 of TP53 gene was characterized as a risk factor in development of cervical cancer. However, the role of this polymorphism remains controversial and some authors suggested that the origin of DNA (blood or exfoliated cervical...
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