Article
p53 polymorphism at codon 72 is not a risk factor for cervical carcinogenesis in central Italy.
Anticancer research - 1 Jan 2000
Cenci Maria, French Deborah, Pisani Tiziana, Alderisio Mauro, Lombardi Anna Maria, Marchese Rodolfo, Colelli Fabrizio, Vecchione Aldo
Abstract excerpt
Recently Storey et al. showed that p53 polymorphism at codon 72 was related to cervical cancer. This polymorphism encodes either arginine (p53Arg) or proline (p53Pro). p53Arg was found to be more susceptible than p53Pro to E6-mediated degradation. Many studies were performed but conclusions are controversial. In this paper, we report our results from 80 women of central Italy, 30 patients showing High-grade...
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