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Article

A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.

International journal of molecular medicine - 1 Feb 2008

Bai Chunying, Matsui Eiko, Ohnishi Hidenori, Kimata Kaori, Kasahara Kimiko, Kaneko Hideo, Kato Zenichiro, Fukao Toshiyuki, Kondo Naomi

Abstract excerpt

Cysteinyl-leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase. We identified a novel polymorphism, c.760 G>A (E254K), in exon 6 of the 5-lipoxygenase gene (5-LO). This substitution was detected in 11 out of 180 patients with BA, but not in any of the 150 non-allergic subjects. The frequency of c.760 G>A showed a...

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PMID: 18204779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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