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Article

Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations.

European journal of pharmacology - 19 Nov 2008

Rivers Francesca, O'Brien Terence J, Callaghan Richard

Abstract excerpt

Approximately one-third of patients with epilepsy display an inherent resistance to pharmacological therapy, manifest as continuing seizures despite maximal tolerated doses of anti-epileptic drugs. One hypothesis for the underlying mechanism of anti-epileptic drug pharmacoresistance is lower drug entry to the epileptic neurones due to the activity of multidrug efflux pumps from the ATP Binding Cassette (ABC)...

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Source

Identifiers

PMID: 18835265
DOI: 10.1016/j.ejphar.2008.09.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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