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Article

Evidence of Key Role of Cdk2 Overexpression in Pemphigus Vulgaris

16 Jan 2008

Abstract excerpt

The pathogenesis of pemphigus vulgaris (PV) is still poorly understood. Autoantibodies present in PV patients can promote detrimental effects by triggering altered transduction of signals, which results in a final acantholysis. To investigate mechanisms involved in PV, cultured keratinocytes were treated with PV serum. PV sera were able to promote the cell cycle progression, inducing the accumulation of...

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PMID: 18199752
DOI: 10.1074/jbc.m702186200

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