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Article

Plakoglobin‐dependent disruption of the desmosomal plaque in pemphigus vulgaris

21 May 2007

Abstract excerpt

We recently reported that the pathogenesis of pemphigus vulgaris (PV), an autoimmune blistering skin disorder, is driven by the accumulation of c-Myc secondary to abrogation of plakoglobin (PG)-mediated transcriptional c-Myc suppression. PG knock-out mouse keratinocytes express high levels of c-Myc and resemble PVIgG-treated wild-type keratinocytes in most respects. However, they fail to accumulate nuclear c-Myc...

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PMID: 17518986
DOI: 10.1111/j.1600-0625.2007.00557.x

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