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Article

Pemphigus-A Disease of Desmosome Dysfunction Caused by Multiple Mechanisms.

Frontiers in immunology - 1 Jan 2018

Spindler Volker, Waschke Jens

Abstract excerpt

Pemphigus is a severe autoimmune-blistering disease of the skin and mucous membranes caused by autoantibodies reducing desmosomal adhesion between epithelial cells. Autoantibodies against the desmosomal cadherins desmogleins (Dsgs) 1 and 3 as well as desmocollin 3 were shown to be pathogenic, whereas the role of other antibodies is unclear. Dsg3 interactions can be directly reduced by specific autoantibodies....

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Share to Autoantibodies
Share to Autoimmune Bullous Skin Diseases
Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29449846
DOI: 10.3389/fimmu.2018.00136
PMCID: PMC5799217

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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