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Article

The impact of signaling pathways on the desmosome ultrastructure in pemphigus

15 Jan 2025

Abstract excerpt

Introduction The autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells. Dsgs are clustered by plaque proteins and linked to the keratin cytoskeleton by desmoplakin (Dp). The aim of this study was to identify the impact of several PV-related signaling pathways on desmosome...

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PMID: 39882246
DOI: 10.3389/fimmu.2024.1497241

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