Article
Novel Therapies for Pemphigus Vulgaris.
American journal of clinical dermatology - 1 Dec 2020
Altman Emily M
Abstract excerpt
Pemphigus vulgaris (PV) is a severe chronic autoimmune blistering disease that affects the skin and mucous membranes. It is characterized by suprabasal acantholysis due to disruption of desmosomal connections between keratinocytes. Autoantibodies against desmosomal cadherins, desmoglein 3 and 1, have been shown to induce disease. Certain human leukocyte antigen (HLA) types and non-HLA foci confer genetic...
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