Article
The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans.
Development (Cambridge, England) - 1 Oct 2003
Piotrowski Tatjana, Ahn Dae-gwon, Schilling Thomas F, Nair Sreelaja, Ruvinsky Ilya, Geisler Robert, Rauch Gerd-Jörg, Haffter Pascal, Zon Leonard I, Zhou Yi, Foott Helen, Dawid Igor B, Ho Robert K
Abstract excerpt
The van gogh (vgo) mutant in zebrafish is characterized by defects in the ear, pharyngeal arches and associated structures such as the thymus. We show that vgo is caused by a mutation in tbx1, a member of the large family of T-box genes. tbx1 has been recently suggested to be a major contributor to the cardiovascular defects in DiGeorge deletion syndrome (DGS) in humans, a syndrome in which several neural crest...
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