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Article

Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

Developmental biology - 15 Mar 2003

Ivey Kathryn, Tyson Brandi, Ukidwe Pallavi, McFadden David G, Levi Giovanni, Olson Eric N, Srivastava Deepak, Wilkie Thomas M

Abstract excerpt

Endothelin-A (ET(A)) is a G-protein-coupled receptor expressed in the neural crest-derived mesenchyme of the pharyngeal arches during craniofacial development. Targeted deletion of the ET(A) receptor or its ligand endothelin-1 (ET-1) causes cleft palate and hypoplasia of the mandible, otic cup, a...

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Source

Identifiers

PMID: 12648486
DOI: 10.1016/s0012-1606(02)00097-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12648486-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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