Article
Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.
Science (New York, N.Y.) - 15 Jan 2010
Chan Yingguang Frank, Marks Melissa E, Jones Felicity C, Villarreal Guadalupe, Shapiro Michael D, Brady Shannon D, Southwick Audrey M, Absher Devin M, Grimwood Jane, Schmutz Jeremy, Myers Richard M, Petrov Dmitri, Jónsson Bjarni, Schluter Dolph, Bell Michael A, Kingsley David M
Abstract excerpt
The molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred through regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox transcription factor 1 (Pitx1) gene. The high prevalence of deletion mutations at Pitx1 may be influenced by...
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