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PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome.

Cardiovascular diabetology - 14 Dec 2011

Passaro Angela, Dalla Nora Edoardo, Marcello Caterina, Di Vece Francesca, Morieri Mario Luca, Sanz Juana M, Bosi Cristina, Fellin Renato, Zuliani Giovanni

Abstract excerpt

BACKGROUND: Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-γ2 (PPARγ2) Pro12Ala and Angiotensin Converting Enzyme (ACE) I/D polymorphisms with MetS and interaction between these genetic variants. METHODS: Three hundred sixty four unrelated Caucasian subjects were enrolled. Waist...

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Amino Acid Substitution
Body Fat Distribution
Body Mass Index
DNA Primers
INDEL Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Syndrome

Peptidyl-Dipeptidase A

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PMID: 22168210
DOI: 10.1186/1475-2840-10-112
PMCID: PMC3295652

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ACE

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PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome.PMID 22168210Read ↗

Effects of Pro12Ala polymorphism in peroxisome proliferator-activated receptor-γ2 gene on metabolic syndrome risk: a meta-analysis.Semantic proximity Read ↗

A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.Semantic proximity Read ↗

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Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ.Semantic proximity Read ↗

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