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Article

Hypermethylation of the CD44 gene is associated with progression and metastasis of human prostate cancer

25 Sept 2001

Abstract excerpt

BACKGROUND: CD44 is a metastasis suppressor gene for prostate cancer and the down-regulation of CD44 and its variants is associated with the progression of prostate cancer. Also, hypermethylation of the CpG islands of the CD44 gene is closely associated with transcriptional inactivation, resulting in the decreased expression of CD44. To clarify the exact role of methylation status of CpG islands of CD44 gene in...

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PMID: 11582589
DOI: 10.1002/pros.1124

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