Article
Integrative genome-wide expression profiling identifies three distinct molecular subgroups of renal cell carcinoma with different patient outcome.
BMC cancer - 23 Jul 2012
Beleut Manfred, Zimmermann Philip, Baudis Michael, Bruni Nicole, Bühlmann Peter, Laule Oliver, Luu Van-Duc, Gruissem Wilhelm, Schraml Peter, Moch Holger
Abstract excerpt
BACKGROUND: Renal cell carcinoma (RCC) is characterized by a number of diverse molecular aberrations that differ among individuals. Recent approaches to molecularly classify RCC were based on clinical, pathological as well as on single molecular parameters. As a consequence, gene expression patterns reflecting the sum of genetic aberrations in individual tumors may not have been recognized. In an attempt to...
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