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Article

Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21.

Journal of neurochemistry - 1 May 2008

Furukawa Keiko, Aixinjueluo Wei, Kasama Takeshi, Ohkawa Yuki, Yoshihara Michiko, Ohmi Yusuke, Tajima Orie, Suzumura Akio, Kittaka Daiji, Furukawa Koichi

Abstract excerpt

GM2/GD2 synthase gene knockout mice lack all complex gangliosides, which are abundantly expressed in the nervous systems of vertebrates. In turn, they have increased precursor structures GM3 and GD3, probably replacing the roles of the depleted complex gangliosides. In this study, we found that 9-O-acetyl GD3 is also highly expressed as one of the major glycosphingolipids accumulating in the nervous tissues of...

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Identifiers

PMID: 18194438
DOI: 10.1111/j.1471-4159.2008.05232.x
PMCID: PMC2408653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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