Article
Clone clusters in autoreactive CD4 T-cell lines from probable multiple sclerosis patients form disease-characteristic signatures.
Immunology - 1 Oct 2009
Mandel Mathilda, Achiron Anat, Tuller Tamir, Barliya Tilda, Rechavi Gideon, Amariglio Ninette, Loewenthal Ron, Lavie Gad
Abstract excerpt
We developed a method for selectively propagating disease-related autoreactive T-cell lines (auTCLs) based on their increased resistance to apoptosis. The generated auTCLs homogeneously co-express CD45RO and CD49a, adhere strongly to extracellular matrix proteins and express high interleukin-17 (...
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