Article
Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999
Bieganowska K, Höllsberg P, Buckle G J, Lim D G, Greten T F, Schneck J, Altman J D, Jacobson S, Ledis S L, Hanchard B, Chin J, Morgan O, Roth P A, Hafler D A
Abstract excerpt
Human T cell lymphotropic virus-I (HTLV-I)-associated myelopathy is a slowly progressive neurologic disease characterized by inflammatory infiltrates in the central nervous system accompanied by clonal expansion of HTLV-I-reactive CD8+ T-cells. In patients carrying the HLA-A2 allele, the immune r...
Topics
- Adult
- B7-1 Antigen
- CD28 Antigens
- CD8-Positive T-Lymphocytes
- Female
- Gene Products, tax
- HLA-A2 Antigen
- Human T-lymphotropic virus 1
- Humans
- Lymphocyte Activation
- Male
- Middle Aged
- Paraparesis, Tropical Spastic