Article
Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study.
American journal of hypertension - 1 Feb 2008
Franceschini Nora, MacCluer Jean W, Rose Kathreen M, Rutherford Sue, Cole Shelley A, Laston Sandy, Göring Harald H H, Diego Vincent P, Roman Mary J, Lee Elisa T, Best Lyle G, Howard Barbara V, Fabsitz Richard R, North Kari E
Abstract excerpt
BACKGROUND: Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS: To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SHFS). Blood pressure was measured three times and the average of the last two measures was used...
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