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Article

Genome-wide association analysis of pulse wave velocity traits provide new insights into the causal relationship between arterial stiffness and blood pressure.

PloS one - 1 Jan 2020

Rode Michael, Teren Andrej, Wirkner Kerstin, Horn Katrin, Kirsten Holger, Loeffler Markus, Scholz Markus, Pott Janne

Abstract excerpt

BACKGROUND: The pathophysiology of arterial stiffness is not completely understood. Pulse wave velocity (PWV) is an established marker for arterial stiffness. We compare genetics of three PWV modes, namely carotid-femoral PWV (cfPWV), brachial-ankle (baPWV) and brachial-femoral (bfPWV), reflecting different vascular segments to analyse association with genetic variants, heritability and genetic correlation with...

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Identifiers

PMID: 32790701
DOI: 10.1371/journal.pone.0237237
PMCID: PMC7425880

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