Article
A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.
American journal of respiratory and critical care medicine - 15 Aug 2012
Desai Ankit A, Zhou Tong, Ahmad Homaa, Zhang Wei, Mu Wenbo, Trevino Sharon, Wade Michael S, Raghavachari Nalini, Kato Gregory J, Peters-Lawrence Marlene H, Thiruvoipati Tejas, Turner Kristin, Artz Nicole, Huang Yong, Patel Amit R, Yuan Jason X-J, Gordeuk Victor R, Lang Roberto M, Garcia Joe G N, Machado Roberto F
Abstract excerpt
RATIONALE: An increased tricuspid regurgitation jet velocity (TRV > 2.5 m/s) and pulmonary hypertension defined by right heart catheterization both independently confer increased mortality in sickle cell disease (SCD). OBJECTIVES: We explored the usefulness of peripheral blood mononuclear cell-derived gene signatures as biomarkers for an elevated TRV in SCD. METHODS: Twenty-seven patients with SCD underwent...
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