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Article

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease.

American journal of hematology - 1 Jan 2008

Taylor James G, Ackah Diana, Cobb Crystal, Orr Nick, Percy Melanie J, Sachdev Vandana, Machado Roberto, Castro Oswaldo, Kato Gregory J, Chanock Stephen J, Gladwin Mark T

Abstract excerpt

Pulmonary hypertension is a common complication of sickle cell disease (SCD) and a risk factor for early death. Hemolysis may participate in its pathogenesis by limiting nitric oxide (NO) bioavailability and producing vasculopathy. We hypothesized that hemoglobin mutations that diminish hemolysis in SCD would influence pulmonary hypertension susceptibility. Surprisingly, coincident alpha-thalassemia (Odds Ratio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anemia, Sickle Cell

Share to Chromatography, High Pressure Liquid

Share to Chromosomes, Human, Pair 11

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Source

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Identifiers

PMID: 17724704
DOI: 10.1002/ajh.21035
PMCID: PMC3509176

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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