Article
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.
Blood - 15 Mar 2008
Garzon Ramiro, Volinia Stefano, Liu Chang-Gong, Fernandez-Cymering Cecilia, Palumbo Tiziana, Pichiorri Flavia, Fabbri Muller, Coombes Kevin, Alder Hansjuerg, Nakamura Tatsuya, Flomenberg Neal, Marcucci Guido, Calin George A, Kornblau Steven M, Kantarjian Hagop, Bloomfield Clara D, Andreeff Michael, Croce Carlo M
Abstract excerpt
MicroRNAs (miRNAs) are small RNAs of 19 to 25 nucleotides that are negative regulators of gene expression. To determine whether miRNAs are associated with cytogenetic abnormalities and clinical features in acute myeloid leukemia (AML), we evaluated the miRNA expression of CD34(+) cells and 122 untreated adult AML cases using a microarray platform. After background subtraction and normalization using a set of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.