Article
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
Nature medicine - 1 Apr 2006
van Hall Thorbald, Wolpert Elisabeth Z, van Veelen Peter, Laban Sandra, van der Veer Michael, Roseboom Marjet, Bres Sandra, Grufman Per, de Ru Arnoud, Meiring Hugo, de Jong Ad, Franken Kees, Teixeira Antoinette, Valentijn Rob, Drijfhout Jan Wouter, Koning Frits, Camps Marcel, Ossendorp Ferry, Kärre Klas, Ljunggren Hans-Gustaf, Melief Cornelis J M, Offringa Rienk
Abstract excerpt
Defects in major histocompatibility complex (MHC) class I-restricted antigen presentation are frequently observed in human cancers and result in escape of tumors from cytotoxic T lymphocyte (CTL) immune surveillance in mice. Here, we show the existence of a unique category of CTLs that can prevent this escape. The CTLs target an alternative repertoire of peptide epitopes that emerge in MHC class I at the surface...
Topics
- Animals
- Antigen Presentation
- Antiporters
- CD8-Positive T-Lymphocytes
- Cell Line, Transformed
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Cell Transformation, Viral