Article
Reversing the "cold" tumor microenvironment: the role of neoantigen vaccines in prostate cancer.
Journal of translational medicine - 25 Jul 2025
Wang Jiani, Guo Rui, Zhang Luyao, Zuo Wen, Li Xuan, Zhang Sha, Tan Qin, Ma Jie
Abstract excerpt
BACKGROUND: Prostate cancer (PCa) is a common malignancy with a "cold" tumor microenvironment (TME) that limits immunotherapy efficacy. Neoantigens from non-synonymous mutations are potential immunotherapeutic targets. METHODS: We identified the neoantigens map in the RM-1 murine prostate cancer model by the whole exome sequencing. The immunogenicity of the identified neoantigens was subsequently assessed using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.