Resampling-based analyses of the effects of combinations of HIV genetic mutations on drug susceptibility.

Abstract excerpt

Viral genotype data aid in understanding the development of antiretroviral drug resistance and in identifying appropriate treatments. Using HIV-1 protease sequences and measures of in vitro sensitivity to the drug amprenavir, we develop a novel statistical approach that can be used to investigate combinations of mutations that alter drug susceptibility. Our method is based on the use of order statistics whose...

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