Article
Clinical manifestations and analyses of the cytotoxic T-lymphocyte associated-4 gene in two Japanese families with systemic lupus erythematosus.
Clinical and experimental nephrology - 1 Apr 2008
Sugimoto Keisuke, Fujita Shinsuke, Yanagida Hidehiko, Shimada Yoshihiro, Tabata Nobutada, Yagi Kazuro, Okada Mitsuru, Takemura Tsukasa
Abstract excerpt
Although still incompletely understood, the etiology of systemic lupus erythematosus (SLE) is considered to involve both genetic and environmental factors. We encountered two boys with severe SLE from unrelated families and analyzed the gene that encodes cytotoxic T-lymphocyte-associated (CTLA)-4, a protein important in T-cell activation and immune tolerance. Abnormal function of the gene may participate in...
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