Article
Pentamidine sensitivity and resistance in Saccharomyces cerevisiae as a model for pentamidine effects on Pneumocystis carinii.
The Journal of protozoology - 1 Jan 2000
Hatfield C, Kasarskis A, Staben C
Abstract excerpt
Pentamidine isethionate inhibits growth of Saccharomyces cerevisiae. Inhibition requires lower drug concentrations under respiratory than fermentative growth conditions. Pentamidine-resistant strains bear heritable resistance mutations. Tested mutations are dominant to wild type sensitivity. These mutations may identify cellular targets of pentamidine and potential mechanisms of fungal pentamidine resistance.
Topics
- Cations, Divalent
- Drug Resistance, Microbial
- Models, Biological
- Mutation
- Pentamidine
- Pneumocystis
- Saccharomyces cerevisiae