Pentamidine sensitivity and resistance in Saccharomyces cerevisiae as a model for pentamidine effects on Pneumocystis carinii.

Abstract excerpt

Pentamidine isethionate inhibits growth of Saccharomyces cerevisiae. Inhibition requires lower drug concentrations under respiratory than fermentative growth conditions. Pentamidine-resistant strains bear heritable resistance mutations. Tested mutations are dominant to wild type sensitivity. These mutations may identify cellular targets of pentamidine and potential mechanisms of fungal pentamidine resistance.

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