Article
Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum.
Eukaryotic cell - 1 Nov 2007
Smulian A George, Gibbons Reta S, Demland Jeffery A, Spaulding Deborah T, Deepe George S
Abstract excerpt
The Escherichia coli hygromycin phosphotransferase (hph) gene, which confers hygromycin resistance, is commonly used as a dominant selectable marker in genetically modified bacteria, fungi, plants, insects, and mammalian cells. Expression of the hph gene has rarely been reported to induce effects other than those expected. Hygromycin B is the most common dominant selectable marker used in the molecular...
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