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Article

Effects of pentamidine isethionate on Saccharomyces cerevisiae.

Antimicrobial agents and chemotherapy - 1 May 1994

Ludewig G, Williams J M, Li Y, Staben C

Abstract excerpt

We used Saccharomyces cerevisiae as a model system in which to examine the mechanism of action of the anti-Pneumocystis drug pentamidine. Pentamidine at low concentrations inhibited S. cerevisiae growth on nonfermentable carbon sources (50% inhibitory concentration [IC50] of 1.25 micrograms/ml in glycerol). Pentamidine inhibited growth on fermentable energy sources only at much higher concentrations (IC50 of 250...

Topics

Genotype
Indicators and Reagents
Mitochondria
Mutagenesis
Oxygen Consumption
Pentamidine
Saccharomyces cerevisiae

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8067749
DOI: 10.1128/AAC.38.5.1123
PMCID: PMC188161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8067749-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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