Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The rise and fall of the common disease-common variant (CD-CV) hypothesis: how the sickle cell disease paradigm led us all astray (or did it?).

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Dec 2007

Mayo Oliver

Abstract excerpt

The common disease-common variant (CD-CV) hypothesis requires an explanation for the origin of the variation observed, since substantial neutral, but not deleterious, variation, that is, several alleles each at moderate to high frequency, can be maintained at any gene/locus by mutation. It is argued here that the guiding principle, not always stated, has been balancing selection, influenced by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Diseases, Inborn
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Malaria

Share to Models, Genetic

Share to Mutation

Share to Polymorphism, Genetic

Share to Selection, Genetic

Source

Identifiers

PMID: 18179390
DOI: 10.1375/twin.10.6.793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The rise and fall of the common disease-common variant (CD-CV) hypothesis: how the sickle cell disease paradigm led us all astray (or did it?).PMID 18179390Read ↗

Common vs. rare allele hypotheses for complex diseases.Semantic proximity Read ↗

Sickle cell disease: no longer a single gene disorder.Semantic proximity Read ↗

Why are some genetic diseases common? Distinguishing selection from other processes by molecular analysis of globin gene variants.Semantic proximity Read ↗

The genetics of common diseases: the implications of population variability.Semantic proximity Read ↗

Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the MediterraneanSemantic proximity Read ↗

G6PD deficiency: a polymorphism balanced by heterozygote advantage against malariaSemantic proximity Read ↗

Variability of homozygous sickle cell disease: The role of alpha and beta globin chain variation and other factors.Semantic proximity Read ↗

The natural history of sickle cell disease.Semantic proximity Read ↗

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles.Semantic proximity Read ↗

The mind of primitive anthropologists: hemoglobin and HLA, patterns of molecular evolution.Semantic proximity Read ↗

The phenotypic diversity of monogenic disease: lessons from the thalassemias.Semantic proximity Read ↗

The population genetics of the haemoglobinopathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.