Article
Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T-cell development.
Nature communications - 1 Jan 2013
Li Jie, Liu Zhijie, Xiao Shiyun, Manley Nancy R
Abstract excerpt
The thoracic thymus is the primary vertebrate organ for T-cell generation. Accessory cervical thymi have also been identified in humans and mice, and shown in mice to be independent functional organs that support T-cell development. However, their origin and functional significance remain unclear. Here we show that cervical thymi in mice have following two origins: delayed differentiation of endodermal precursors...
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