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Gene Overexpression/Suppression Analysis of Candidate Virulence Factors of Candida albicans

4 Jan 2008

Abstract excerpt

We developed a conditional overexpression/suppression genetic strategy in Candida albicans to enable simultaneous testing of gain or loss of function in order to identify new virulence factors. The strategy involved insertion of a strong, tetracycline-regulated promoter in front of the gene of interest. To validate the strategy, a library of genes encoding glycosylphosphatidylinositol (GPI)-anchored surface...

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PMID: 18178776
DOI: 10.1128/ec.00445-07

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