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Article

Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut

11 Jul 2018

Abstract excerpt

Candida albicans is part of the human gastrointestinal (GI) microbiota. To better understand how C. albicans efficiently establishes GI colonisation, we competitively challenged growth of 572 signature-tagged strains (~10% genome coverage), each conditionally overexpressing a single gene, in the murine gut. We identified CRZ2, a transcription factor whose overexpression and deletion respectively increased and...

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PMID: 29998470
DOI: 10.1111/cmi.12890

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