Article
Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease.
PloS one - 1 Jan 2011
Chaturvedi Ashok K, Lazzell Anna L, Saville Stephen P, Wormley Floyd L, Monteagudo Carlos, Lopez-Ribot Jose L
Abstract excerpt
Understanding the pathogenesis of infectious disease requires the examination and successful integration of parameters related to both microbial virulence and host responses. As a practical and powerful method to control microbial gene expression, including in vivo, the tetracycline-regulatable system has recently gained the favor of many investigative groups. However, some immunomodulatory effects of the...
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