Article
TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Molecular cell - 1 Oct 2015
Stadel Daniela, Millarte Valentina, Tillmann Kerstin D, Huber Jessica, Tamin-Yecheskel Bat-Chen, Akutsu Masato, Demishtein Alik, Ben-Zeev Bruria, Anikster Yair, Perez Franck, Dötsch Volker, Elazar Zvulun, Rogov Vladimir, Farhan Hesso, Behrends Christian
Abstract excerpt
Hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative diseases that are characterized by axonopathy of the corticospinal motor neurons. A mutation in the gene encoding for Tectonin β-propeller containing protein 2 (TECPR2) causes HSP that is complicated by neurological symptoms. While TECPR2 is a human ATG8 binding protein and positive regulator of autophagy, the exact function of TECPR2...
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