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Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes

4 Feb 2008

Abstract excerpt

Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change gene expression. Using pathway-specific transcriptional profiling, we identified the genes regulated by two such pathways, p38 and ERK. These pathways are at the fulcrum of epidermal differentiation, proliferative and inflammatory skin diseases. We used SB203580 and PD98059 as specific...

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PMID: 18247374
DOI: 10.1002/jcp.21394

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