Article
Polymorphisms in Toll-like receptor genes and risk of cancer.
Oncogene - 7 Jan 2008
El-Omar E M, Ng M T, Hold G L
Abstract excerpt
Host genetic factors are emerging as key determinants of disease risk for many cancers. Identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. The Toll-like receptors are important members of the host's innate immune response and their genes have been found to be polymorphic. This genetic variation allows for a more intricate...
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